DHRS12

Across TCGA patient cohorts, DHRS12 mutation is significantly associated with the RNA expression of many other genes, with 1,131 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHRS12-associated genes across cancer lineages are MIR8053, RBX1P1, and SIGLEC24P. Each is linked with DHRS12 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHRS12-to-partner and partner-to-DHRS12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8053 grouped by DHRS12-low versus DHRS12-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHRS12→partner) and Y-score (partner→DHRS12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR8053 →	+0.732	+5.409	<.001	.005	3	2
BLCA	RBX1P1 →	+0.094	+7.640	<.001	.009	3	2
SKCM	SIGLEC24P →	+0.051	+4.771	<.001	.006	3	2
UCEC	NUTF2P8 →	+0.114	+2.497	<.001	.003	3	1
UCEC	ATP1B3P1 →	+0.293	+1.949	<.001	.009	3	1
UCEC	PLS3-AS1 →	+0.257	+3.552	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,131 associations by consensus.

MIR8053 by DHRS12 expression — BRCA

Explore this box plot interactively →