DHRS1

Across TCGA patient cohorts, DHRS1 mutation is significantly associated with the immune_cell of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHRS1-associated genes across cancer lineages are NK cells, Endothelial cells, and lymphatic Endothelial cells. Each is linked with DHRS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHRS1-to-partner and partner-to-DHRS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NK cells grouped by DHRS1-low versus DHRS1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHRS1→partner) and Y-score (partner→DHRS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	NK cells →	+0.009	+5.597	<.001	.040	3	1
UCEC	Endothelial cells →	-0.046	-3.416	.016	.005	3	1
UCEC	lymphatic Endothelial cells →	-0.026	-2.268	.032	.036	3	1
UCEC	mv Endothelial cells →	-0.028	-2.947	.020	.036	3	1
UCEC	pDC →	+0.078	+3.032	.001	.018	3	1
UCEC	Basophils →	+0.217	+2.321	.010	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

NK cells by DHRS1 expression — STAD

Explore this box plot interactively →