DHRS1

Across TCGA pan-cancer cohorts, DHRS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated DHRS1 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher DHRS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated DHRS1 expression acts as an unfavorable survival marker, although some lineages such as MESO and SCLC show a favorable association.

MESO, KICH, and ACC are the cancer types where DHRS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.499	0.280	<.001	73	view →
KICH	DFS	Median	II,III,IV	0.558	1.000	.003	69	view →
ACC	DFS	Median	All	0.168	0.668	<.001	58	view →
HNSC	DFS	Median	IV	0.205	0.409	<.001	46	view →
SCLC	OS	Tertile	All	0.872	0.547	<.001	38	view →
READ	DFS	Tertile	IV	0.908	0.376	.003	33	view →
KIRC	DFS	Median	All	0.762	0.504	<.001	32	view →
LIHC	OS	Median	All	0.767	0.603	<.001	29	view →
KIRP	OS	Median	III,IV	0.882	0.661	.008	26	view →
OV	OS	Tertile	IV	0.236	0.518	.002	20	view →
LGG	DFS	Tertile	All	0.654	0.802	.001	16	view →
BRCA	OS	Median	II,III,IV	0.617	0.530	.019	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

DHRS1–MESO (OS)

Open the MESO breakdown →