DHODH

Across TCGA patient cohorts, DHODH protein abundance is significantly associated with the RNA expression of many other genes, with 9,439 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DHODH-associated genes across cancer lineages are MYCT1, CALHM2, and PPP1R18. Each is linked with DHODH in more than 4 cancer types. Because this analysis shows association rather than direction, both DHODH-to-partner and partner-to-DHODH results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DHODH versus MYCT1 in UCEC, with a Pearson correlation of -0.29.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHODH→partner) and Y-score (partner→DHODH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MYCT1 →	-0.811	-0.329	.001	.005	3	5
UCEC	CALHM2 →	-0.930	-0.372	<.001	.001	3	5
OV	PPP1R18 →	-1.075	-0.508	<.001	<.001	3	5
UCEC	ANTXR2 →	-0.895	-0.353	<.001	.003	3	5
OV	TMEM200A →	-0.686	-0.361	<.001	<.001	3	5
LSCC	NIP7 →	+0.527	+0.354	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,439 associations by consensus.

DHODH vs MYCT1 — UCEC

Explore this scatter interactively →