DHODH

Across TCGA pan-cancer cohorts, DHODH RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated DHODH data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher DHODH RNA is associated with better overall survival. In most high-consensus cancer types, elevated DHODH expression acts as an unfavorable survival marker, although some lineages such as MESO and THYM show a favorable association.

MESO, THYM, and BLCA are the cancer types where DHODH RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.659	0.425	<.001	93	view →
THYM	DFS	Tertile	All	0.976	0.770	<.001	52	view →
BLCA	DFS	Quartile	All	0.452	0.779	.002	42	view →
UCS	OS	Median	II,III,IV	0.640	0.352	.019	38	view →
LGG	DFS	Tertile	All	0.758	0.879	<.001	35	view →
KIRC	DFS	Median	All	0.750	0.505	.001	22	view →
COAD	DFS	Quartile	III,IV	0.280	0.870	.007	18	view →
HNSC	OS	Tertile	All	0.254	0.544	.001	17	view →
LIHC	OS	Median	II,III,IV	0.551	0.296	.005	16	view →
ACC	OS	Quartile	IV	0.293	0.747	.006	15	view →
LUSC	OS	Median	IV	0.255	0.851	.021	14	view →
LUAD	DFS	Tertile	IV	0.840	0.354	.013	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

DHODH–MESO (OS)

Open the MESO breakdown →