DHODH

Across TCGA patient cohorts, DHODH mutation is significantly associated with the total protein of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHODH-associated genes across cancer lineages are JNK2, TSC1, and STAT3_pY705. Each is linked with DHODH in more than 1 cancer types. Because this analysis shows association rather than direction, both DHODH-to-partner and partner-to-DHODH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by DHODH-low versus DHODH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHODH→partner) and Y-score (partner→DHODH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.360	+2.817	<.001	.036	3	1
UCEC	TSC1 →	-0.265	-3.000	.004	.036	2	2
UCEC	STAT3_pY705 →	-0.393	-3.169	.006	.020	1	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

JNK2 by DHODH expression — UCEC

Explore this box plot interactively →