DHODH

Across TCGA cell cohorts, DHODH mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DHODH-associated genes across cancer lineages are DEFA4 and SLC4A1. Each is linked with DHODH in more than 1 cancer types. Because this analysis shows association rather than direction, both DHODH-to-partner and partner-to-DHODH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA4 grouped by DHODH-low versus DHODH-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHODH→partner) and Y-score (partner→DHODH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	SLC4A1 →	+0.036	+3.658	.003	.005	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

DEFA4 by DHODH expression — LARGE_INTESTINE

Explore this box plot interactively →