DHODH

Across TCGA cell cohorts, DHODH mutation is significantly associated with the mutation status of many other genes, with 3,214 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DHODH-associated genes across cancer lineages are CDC37, PRPF31, and RBM25. Each is linked with DHODH in more than 2 cancer types. Because this analysis shows association rather than direction, both DHODH-to-partner and partner-to-DHODH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDC37 grouped by DHODH-low versus DHODH-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHODH→partner) and Y-score (partner→DHODH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CDC37 →	+5.584	+5.014	.003	.003	1	3
BLOOD_Leukemia	PRPF31 →	+5.894	+5.321	.002	.002	1	3
BLOOD_Lymphoma	RBM25 →	+4.169	+5.316	<.001	<.001	1	3
BLOOD_Lymphoma	SGSM2 →	+5.584	+5.014	.003	.003	1	3
BLOOD_Lymphoma	PADI3 →	+4.584	+4.584	.007	.007	1	3
BLOOD_Lymphoma	ZNF462 →	+2.710	+4.203	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,214 associations by consensus.

CDC37 by DHODH expression — BLOOD_Lymphoma

Explore this box plot interactively →