DHFR2

Across TCGA patient cohorts, DHFR2 mutation is significantly associated with the RNA expression of many other genes, with 693 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHFR2-associated genes across cancer lineages are RN7SL148P, RNU6-492P, and CHEK2P5. Each is linked with DHFR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DHFR2-to-partner and partner-to-DHFR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL148P grouped by DHFR2-low versus DHFR2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHFR2→partner) and Y-score (partner→DHFR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL148P →	+0.120	+5.993	<.001	.001	3	2
HNSC	RNU6-492P →	+0.478	+7.954	<.001	.008	3	2
COAD	CHEK2P5 →	+0.203	+4.418	.007	.008	3	2
UCEC	EIF3JP1 →	+0.254	+2.257	<.001	.009	3	2
UCEC	RNA5SP24 →	+0.844	+2.713	<.001	.002	3	2
LUSC	RNU6-468P →	+0.405	+4.393	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 693 associations by consensus.

RN7SL148P by DHFR2 expression — SKCM

Explore this box plot interactively →