Across TCGA patient cohorts, DHFR RNA expression is significantly associated with the protein abundance of many other proteins, with 19,110 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DHFR-associated proteins across cancer lineages are MCM2, MCM3, and MCM4. Each is linked with DHFR in more than 9 cancer types. Because this analysis shows association rather than direction, both DHFR-to-partner and partner-to-DHFR results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DHFR→partner) and Y-score (partner→DHFR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MCM2 →	+0.760	+0.681	<.001	<.001	3	10
GBM	MCM3 →	+0.814	+0.738	<.001	<.001	3	10
GBM	MCM4 →	+0.781	+0.652	<.001	<.001	3	10
GBM	MCM5 →	+0.806	+0.728	<.001	<.001	3	10
GBM	MCM6 →	+0.896	+0.670	<.001	<.001	3	10
GBM	MCM7 →	+0.821	+0.702	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,110 associations by consensus.

Exploration

DHFR survival (RNA) · tumor vs normal (RNA) · all DHFR data types