DHDDS

Across TCGA cell cohorts, DHDDS mutation is significantly associated with the mutation status of many other genes, with 2,418 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DHDDS-associated genes across cancer lineages are PTK6, DDX49, and SCARF1. Each is linked with DHDDS in more than 2 cancer types. Because this analysis shows association rather than direction, both DHDDS-to-partner and partner-to-DHDDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTK6 grouped by DHDDS-low versus DHDDS-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHDDS→partner) and Y-score (partner→DHDDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PTK6 →	+4.309	+4.560	.007	.007	1	3
BLOOD_Leukemia	DDX49 →	+4.894	+5.870	<.001	<.001	1	3
BLOOD_Leukemia	SCARF1 →	+3.309	+4.794	.002	.002	1	3
BLOOD_Leukemia	DLG4 →	+4.479	+5.635	<.001	<.001	1	3
BLOOD_Leukemia	PLK4 →	+4.309	+4.560	.007	.007	1	3
BLOOD_Leukemia	SCUBE3 →	+3.672	+5.083	.001	.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,418 associations by consensus.

PTK6 by DHDDS expression — BLOOD_Leukemia

Explore this box plot interactively →