DHCR7

Across TCGA pan-cancer cohorts, DHCR7 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of DHCR7’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DHCR7 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types DHCR7 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

COAD, HNSC, and CCRCC are the cancer types where DHCR7 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DHCR7 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+1.103	<.001	11	view →
HNSC	Male	III,IV	+0.714	<.001	9	view →
CCRCC	All	All	−0.260	<.001	7	view →
LSCC	Male	All	+0.420	<.001	5	view →
PDAC	Male	IV	+0.770	.025	3	view →
OV	All	All	+0.643	.002	2	view →
LUAD	Female	III,IV	+0.447	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

DHCR7–COAD

Open the COAD breakdown →