DHCR7

Across TCGA pan-cancer cohorts, DHCR7 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated DHCR7 data layer compared with 4 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher DHCR7 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DHCR7 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SCLC show a favorable association.

CESC, BLCA, and ACC are the cancer types where DHCR7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.665	0.817	<.001	96	view →
BLCA	OS	Median	III,IV	0.272	0.454	.002	58	view →
ACC	DFS	Tertile	All	0.252	0.779	<.001	52	view →
KICH	DFS	Median	II,III,IV	0.694	0.962	.007	49	view →
LUAD	OS	Tertile	All	0.553	0.774	.002	39	view →
HNSC	OS	Quartile	All	0.251	0.649	.003	32	view →
KIRP	DFS	Median	IV	0.036	0.526	.004	31	view →
SARC	OS	Tertile	All	0.634	0.843	<.001	27	view →
UVM	OS	Quartile	III,IV	0.215	0.836	.031	26	view →
UCEC	DFS	Quartile	IV	0.756	0.179	.004	26	view →
LIHC	DFS	Median	All	0.327	0.511	.011	23	view →
SCLC	OS	Tertile	All	0.781	0.533	.008	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

DHCR7–CESC (DFS)

Open the CESC breakdown →