DHCR7

Across TCGA patient cohorts, DHCR7 mutation is significantly associated with the RNA expression of many other genes, with 4,124 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DHCR7-associated genes across cancer lineages are MIR8055, RN7SL26P, and RNA5SP404. Each is linked with DHCR7 in more than 2 cancer types. Because this analysis shows association rather than direction, both DHCR7-to-partner and partner-to-DHCR7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8055 grouped by DHCR7-low versus DHCR7-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHCR7→partner) and Y-score (partner→DHCR7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR8055 →	+0.832	+3.758	.001	.006	3	3
LUAD	RN7SL26P →	+0.105	+3.802	<.001	.003	3	3
LUAD	RNA5SP404 →	+0.223	+4.122	<.001	.009	3	3
SKCM	ABALON →	+0.538	+2.762	.001	.002	3	3
UCEC	RBSN →	+0.376	+2.987	.001	<.001	3	3
UCEC	ARF4P1 →	+0.514	+2.201	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,124 associations by consensus.

MIR8055 by DHCR7 expression — COAD

Explore this box plot interactively →