DHCR7

Across TCGA cell cohorts, DHCR7 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,064 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DHCR7-associated GO terms across cancer lineages are Sterol biosynthetic process, Cholesterol biosynthetic process via desmosterol, and Cholesterol biosynthetic process via lathosterol. Each is linked with DHCR7 in more than 18 cancer types. Because this analysis shows association rather than direction, both DHCR7-to-partner and partner-to-DHCR7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sterol biosynthetic process grouped by DHCR7-low versus DHCR7-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DHCR7→partner) and Y-score (partner→DHCR7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Sterol biosynthetic process →	+0.178	+1.482	<.001	<.001	3	19
STOMACH	Cholesterol biosynthetic process via desmosterol →	+0.233	+1.484	<.001	<.001	3	19
BONE	Cholesterol biosynthetic process via lathosterol →	+0.218	+1.654	<.001	<.001	3	19
STOMACH	Zymosterol metabolic process →	+0.242	+1.571	<.001	<.001	3	19
STOMACH	Zymosterol biosynthetic process →	+0.242	+1.571	<.001	<.001	3	19
STOMACH	Cholesterol biosynthetic process →	+0.201	+1.647	<.001	<.001	2	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,064 associations by consensus.

Sterol biosynthetic process by DHCR7 expression — URINARY_TRACT

Explore this box plot interactively →