DHCR24

Across TCGA pan-cancer cohorts, DHCR24 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DHCR24 data layer compared with 24 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher DHCR24 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DHCR24 expression acts as an unfavorable survival marker.

THYM, BLCA, and LUAD are the cancer types where DHCR24 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
BLCA	OS	Median	All	0.069	0.688	<.001	18	view →
LUAD	OS	Median	All	0.323	0.834	.003	12	view →
PRAD	DFS	Median	All	0.617	0.886	.027	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUSC	OS	Median	All	0.192	0.724	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DHCR24–THYM (OS)

Open the THYM breakdown →