DHCR24-DT

Across TCGA pan-cancer cohorts, DHCR24-DT RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated DHCR24-DT data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DHCR24-DT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DHCR24-DT expression acts as an unfavorable survival marker, although some lineages such as CESC and READ show a favorable association.

UCEC, ACC, and CESC are the cancer types where DHCR24-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.591	0.779	<.001	76	view →
ACC	OS	Quartile	All	0.282	0.932	<.001	62	view →
CESC	OS	Median	III,IV	0.875	0.634	.006	54	view →
LGG	OS	Median	All	0.736	0.872	<.001	42	view →
KIRC	DFS	Median	All	0.480	0.766	<.001	40	view →
LIHC	DFS	Quartile	All	0.441	0.629	.002	34	view →
READ	DFS	Tertile	III,IV	0.833	0.366	.002	30	view →
PAAD	DFS	Quartile	All	0.397	0.633	.003	24	view →
MESO	OS	Median	All	0.480	0.304	.011	23	view →
UCS	DFS	Median	II,III,IV	0.287	0.569	.011	20	view →
UVM	DFS	Quartile	III,IV	0.373	0.755	.012	13	view →
TGCT	DFS	Tertile	All	0.935	0.733	.018	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

DHCR24-DT–UCEC (OS)

Open the UCEC breakdown →