DHCR24-DT

Across TCGA pan-cancer cohorts, DHCR24-DT RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of DHCR24-DT’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where DHCR24-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DHCR24-DT is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

BLCA, KICH, and LUAD are the cancer types where DHCR24-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DHCR24-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	+0.524	.001	8	view →
KICH	Male	All	−0.610	<.001	7	view →
LUAD	Female	III,IV	+0.567	.007	7	view →
BRCA	All	III,IV	+0.636	<.001	6	view →
COAD	Male	II,III,IV	+0.557	<.001	5	view →
HNSC	Male	All	+0.395	.001	4	view →
STAD	All	All	+0.322	.002	3	view →
CHOL	All	All	+0.844	<.001	2	view →
PRAD	All	All	+0.660	<.001	2	view →
KIRP	Male	All	+0.279	.023	2	view →
LUSC	Female	II,III,IV	−0.465	.028	1	view →
KIRC	All	All	+0.148	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

DHCR24-DT–BLCA

Open the BLCA breakdown →