DGLUCY

Across TCGA patient cohorts, DGLUCY mutation is significantly associated with the RNA expression of many other genes, with 3,834 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGLUCY-associated genes across cancer lineages are LONP1, BRI3P2, and RNA5SP155. Each is linked with DGLUCY in more than 1 cancer types. Because this analysis shows association rather than direction, both DGLUCY-to-partner and partner-to-DGLUCY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LONP1 grouped by DGLUCY-low versus DGLUCY-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGLUCY→partner) and Y-score (partner→DGLUCY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LONP1 →	+0.613	+2.332	<.001	<.001	3	2
SKCM	BRI3P2 →	+0.071	+2.365	.008	.007	3	2
UCEC	RNA5SP155 →	+0.475	+1.913	<.001	.001	3	2
SKCM	HIKESHIP1 →	+0.402	+2.267	<.001	.004	3	2
CESC	RNU6-1067P →	+0.255	+4.984	<.001	.003	3	2
UCEC	MED27 →	+0.334	+2.386	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,834 associations by consensus.

LONP1 by DGLUCY expression — UCEC

Explore this box plot interactively →