DGLUCY

Across TCGA patient cohorts, DGLUCY mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGLUCY-associated genes across cancer lineages are ATM, 4E-BP1, and eIF4G. Each is linked with DGLUCY in more than 2 cancer types. Because this analysis shows association rather than direction, both DGLUCY-to-partner and partner-to-DGLUCY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DGLUCY-low versus DGLUCY-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGLUCY→partner) and Y-score (partner→DGLUCY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.578	-3.000	.001	.001	2	3
UCEC	4E-BP1 →	+0.262	+2.489	.019	.010	3	2
UCEC	eIF4G →	+0.262	+1.807	.040	.027	3	1
UCEC	ERK2 →	+0.168	+2.459	.034	.019	3	1
UCEC	FOXO3a_pS318_S321 →	-0.128	-1.807	.012	.027	3	1
UCEC	Ku80 →	+0.280	+2.335	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ATM by DGLUCY expression — UCEC

Explore this box plot interactively →