DGKQ

Across TCGA pan-cancer cohorts, DGKQ mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of DGKQ’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DGKQ mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types DGKQ is over-expressed in tumor, although a few such as COAD and HNSC show the opposite, repressed pattern.

COAD, HNSC, and LSCC are the cancer types where DGKQ tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DGKQ mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−0.797	<.001	9	view →
HNSC	Male	IV	−0.393	<.001	8	view →
LSCC	Male	II,III,IV	−0.386	<.001	8	view →
CCRCC	Male	II,III,IV	+0.172	.008	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

DGKQ–COAD

Open the COAD breakdown →