DGKK

Across TCGA patient cohorts, DGKK RNA expression is significantly associated with the go_rna of many other GO terms, with 7,038 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible DGKK-associated GO terms across cancer lineages are Regulation of DNA-templated transcription elongation, Obsolete histone modification, and Peptidyl-lysine acetylation. Each is linked with DGKK in more than 16 cancer types. Because this analysis shows association rather than direction, both DGKK-to-partner and partner-to-DGKK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of DNA-templated transcription elongation grouped by DGKK-low versus DGKK-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKK→partner) and Y-score (partner→DGKK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of DNA-templated transcription elongation →	+0.107	+0.104	<.001	<.001	3	16
STAD	Obsolete histone modification →	+0.091	+0.079	<.001	<.001	1	17
STAD	Peptidyl-lysine acetylation →	+0.093	+0.078	<.001	<.001	2	16
UCS	Regulation of calcium ion export across plasma membrane →	+0.041	+0.809	<.001	.002	3	15
STAD	Positive regulation of telomere maintenance →	+0.097	+0.064	<.001	<.001	2	16
STAD	Regulation of microtubule polymerization or depolymerization →	+0.083	+0.087	<.001	<.001	2	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,038 associations by consensus.

Regulation of DNA-templated transcription elongation by DGKK expression — STAD

Explore this box plot interactively →