DGKK

Across TCGA pan-cancer cohorts, DGKK RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated DGKK data layer compared with 10 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DGKK RNA is associated with better overall survival. In most high-consensus cancer types, elevated DGKK expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

KIRC, LGG, and OV are the cancer types where DGKK RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.908	0.839	<.001	126	view →
LGG	DFS	Median	All	0.841	0.638	<.001	54	view →
OV	DFS	Quartile	III,IV	0.451	0.335	.007	52	view →
UVM	OS	Tertile	All	0.307	0.679	<.001	43	view →
LIHC	OS	Median	II,III,IV	0.272	0.527	<.001	37	view →
SCLC	DFS	Tertile	III,IV	0.592	0.253	.006	35	view →
HNSC	OS	Tertile	II,III,IV	0.582	0.709	.007	30	view →
THCA	DFS	Median	II,III,IV	0.885	0.675	.004	27	view →
KICH	OS	Median	II,III,IV	0.625	0.929	.008	25	view →
CHOL	DFS	Tertile	All	0.819	0.264	.014	15	view →
STAD	DFS	Quartile	II,III,IV	0.568	0.733	.009	15	view →
UCEC	OS	Tertile	All	0.826	0.908	.010	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

DGKK–KIRC (OS)

Open the KIRC breakdown →