DGKI

Across TCGA patient cohorts, DGKI RNA expression is significantly associated with the protein abundance of many other proteins, with 20,061 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible DGKI-associated proteins across cancer lineages are TIMP2, DPYSL3, and ANTXR1. Each is linked with DGKI in more than 8 cancer types. Because this analysis shows association rather than direction, both DGKI-to-partner and partner-to-DGKI results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DGKI versus TIMP2 in BRCA, with a Pearson correlation of 0.53.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKI→partner) and Y-score (partner→DGKI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TIMP2 →	+0.866	+0.599	<.001	<.001	3	9
COAD	DPYSL3 →	+0.833	+0.406	<.001	<.001	3	9
BRCA	ANTXR1 →	+0.790	+0.625	<.001	<.001	3	9
OV	SNX9 →	+0.416	+0.240	<.001	<.001	3	8
OV	TAGLN →	+1.057	+0.275	<.001	<.001	3	8
UCEC	TLN1 →	+0.491	+0.538	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,061 associations by consensus.

DGKI vs TIMP2 — BRCA

Explore this scatter interactively →