DGKI

Across TCGA patient cohorts, DGKI mutation is significantly associated with the total protein of many other genes, with 81 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGKI-associated genes across cancer lineages are ER-alpha, 4E-BP1, and Cyclin-B1. Each is linked with DGKI in more than 4 cancer types. Because this analysis shows association rather than direction, both DGKI-to-partner and partner-to-DGKI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha grouped by DGKI-low versus DGKI-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKI→partner) and Y-score (partner→DGKI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	ER-alpha →	-0.136	-1.874	.040	.049	3	4
COAD	4E-BP1 →	+0.337	+3.008	.003	.019	2	5
UCEC	Cyclin-B1 →	+0.754	+1.784	<.001	<.001	2	5
STAD	PCNA →	+0.396	+3.459	.001	.004	2	5
UCEC	STAT3_pY705 →	-0.290	-1.736	<.001	.005	3	4
COAD	Caspase-7-cleavedD198 →	+1.116	+3.008	.006	.019	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

ER-alpha by DGKI expression — LUSC

Explore this box plot interactively →