DGKI

Across TCGA cell cohorts, DGKI RNA expression is significantly associated with the go_rna of many other GO terms, with 2,644 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DGKI-associated GO terms across cancer lineages are Positive regulation of supramolecular fiber organization, Regulation of protein localization to mitochondrion, and Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Each is linked with DGKI in more than 8 cancer types. Because this analysis shows association rather than direction, both DGKI-to-partner and partner-to-DGKI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of supramolecular fiber organization grouped by DGKI-low versus DGKI-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKI→partner) and Y-score (partner→DGKI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of supramolecular fiber organization →	+0.078	+1.016	<.001	.006	3	9
LIVER	Regulation of protein localization to mitochondrion →	+0.178	+2.550	<.001	<.001	3	9
BREAST	Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway →	+0.055	+0.986	<.001	.005	3	8
LUNG_NSCLC_LUSC	Wound healing →	+0.113	+1.351	.002	.009	3	8
BONE	Elastin metabolic process →	+0.212	+1.266	.007	.001	3	8
PANCREAS	Positive regulation of extracellular matrix organization →	+0.081	+0.236	<.001	.008	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,644 associations by consensus.

Positive regulation of supramolecular fiber organization by DGKI expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →