DGKI

Across TCGA cell cohorts, DGKI mutation is significantly associated with the RNA expression of many other genes, with 102 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DGKI-associated genes across cancer lineages are OR2H1, OR1L4, and ANKRD60. Each is linked with DGKI in more than 1 cancer types. Because this analysis shows association rather than direction, both DGKI-to-partner and partner-to-DGKI results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2H1 grouped by DGKI-low versus DGKI-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKI→partner) and Y-score (partner→DGKI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR2H1 →	+0.173	+3.866	<.001	.006	3	2
URINARY_TRACT	OR1L4 →	+0.080	+5.087	<.001	.004	3	1
SOFT_TISSUE	ANKRD60 →	+0.015	+4.977	<.001	.002	3	1
SOFT_TISSUE	TGM7 →	+0.004	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR8B12 →	+0.030	+4.369	<.001	.008	3	1
SOFT_TISSUE	OR4X2 →	+0.024	+4.369	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 102 associations by consensus.

OR2H1 by DGKI expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →