DGKH

Across TCGA patient cohorts, DGKH mutation is significantly associated with the RNA expression of many other genes, with 2,952 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGKH-associated genes across cancer lineages are MRPL18, SDHB, and AKR1A1. Each is linked with DGKH in more than 2 cancer types. Because this analysis shows association rather than direction, both DGKH-to-partner and partner-to-DGKH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL18 grouped by DGKH-low versus DGKH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKH→partner) and Y-score (partner→DGKH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL18 →	+0.346	+1.562	<.001	.002	3	3
UCEC	SDHB →	+0.376	+2.513	<.001	<.001	3	3
UCEC	AKR1A1 →	+0.307	+1.950	.001	.002	3	3
UCEC	UBR7 →	+0.452	+2.606	<.001	<.001	3	3
UCEC	GDF15 →	+1.108	+4.010	<.001	<.001	3	3
UCEC	UTP3 →	+0.297	+2.194	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,952 associations by consensus.

MRPL18 by DGKH expression — UCEC

Explore this box plot interactively →