DGKG

Across TCGA pan-cancer cohorts, DGKG Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DGKG data layer compared with 24 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher DGKG Mutation is associated with better overall survival. In most high-consensus cancer types, elevated DGKG expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

BLCA, KICH, and UCEC are the cancer types where DGKG Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	II,III,IV	1.000	0.422	.025	16	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
UCEC	DFS	Median	All	0.971	0.614	.004	12	view →
LUAD	OS	Median	All	0.670	0.814	.029	10	view →
ESCA	OS	Median	All	0.258	0.703	.005	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DGKG–BLCA (OS)

Open the BLCA breakdown →