DGKG

Across TCGA pan-cancer cohorts, DGKG mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DGKG data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DGKG mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DGKG expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and GBM are the cancer types where DGKG mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	1.000	0.127	.038	14	view →
LUAD	OS	Tertile	II,III,IV	0.650	0.291	.034	2	view →
GBM	OS	Quartile	All	0.645	0.359	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DGKG–LSCC (DFS)

Open the LSCC breakdown →