DGKG

Across TCGA patient cohorts, DGKG mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGKG-associated genes across cancer lineages are ERK2, Lck, and PKC-a_pS657. Each is linked with DGKG in more than 2 cancer types. Because this analysis shows association rather than direction, both DGKG-to-partner and partner-to-DGKG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by DGKG-low versus DGKG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKG→partner) and Y-score (partner→DGKG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.193	+2.247	.001	.001	3	3
LUAD	Lck →	-0.319	-2.983	.008	.036	3	2
LUAD	PKC-a_pS657 →	-0.353	-3.000	.040	.036	3	2
LUAD	VHL →	-1.167	-3.000	.015	.036	3	2
SKCM	eEF2 →	+0.301	+1.847	.012	.008	3	2
UCEC	EGFR_pY1068 →	-0.222	-1.765	.005	.013	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

ERK2 by DGKG expression — UCEC

Explore this box plot interactively →