DGKG

Across TCGA cell cohorts, DGKG RNA expression is significantly associated with the go_rna of many other GO terms, with 4,666 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DGKG-associated GO terms across cancer lineages are Negative regulation of cytokine production, Regulation of muscle filament sliding, and Positive regulation of intracellular transport. Each is linked with DGKG in more than 9 cancer types. Because this analysis shows association rather than direction, both DGKG-to-partner and partner-to-DGKG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cytokine production grouped by DGKG-low versus DGKG-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKG→partner) and Y-score (partner→DGKG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of cytokine production →	+0.076	+1.016	<.001	<.001	3	10
PANCREAS	Regulation of muscle filament sliding →	-1.008	-1.463	.007	<.001	3	8
BREAST	Positive regulation of intracellular transport →	+0.067	+1.122	<.001	<.001	3	8
BLOOD_Leukemia	Skeletal myofibril assembly →	+0.535	+1.105	<.001	<.001	3	8
SOFT_TISSUE	Viral life cycle →	+0.087	+1.704	<.001	.001	3	8
UPPER_AERODIGESTIVE_TRACT	Negative regulation of nitric oxide biosynthetic process →	+0.129	+1.035	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,666 associations by consensus.

Negative regulation of cytokine production by DGKG expression — BREAST

Explore this box plot interactively →