DGKD

Across TCGA pan-cancer cohorts, DGKD mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DGKD data layer compared with 25 for mass-spec protein and 11 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DGKD mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DGKD expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

UCEC, LUAD, and HNSC are the cancer types where DGKD mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	III,IV	0.094	0.745	.038	12	view →
LUAD	OS	Quartile	II,III,IV	0.261	0.893	.006	4	view →
HNSC	DFS	Tertile	III,IV	0.805	0.317	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DGKD–UCEC (DFS)

Open the UCEC breakdown →