DGKD

Across TCGA pan-cancer cohorts, DGKD RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of DGKD’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DGKD RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DGKD is over-expressed in tumor, although a few such as LUSC and BLCA show the opposite, repressed pattern.

KIRC, KIRP, and LIHC are the cancer types where DGKD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DGKD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+2.064	<.001	12	view →
KIRP	Female	All	+1.105	<.001	11	view →
LIHC	Female	II,III,IV	+1.314	<.001	9	view →
HNSC	All	II,III,IV	+0.699	<.001	8	view →
CHOL	All	All	+1.780	<.001	5	view →
LUSC	All	All	−0.773	<.001	4	view →
BLCA	All	IV	−0.745	.012	4	view →
KICH	All	All	−0.519	.001	3	view →
THCA	All	All	−0.288	.021	3	view →
STAD	Male	IV	−1.189	.014	2	view →
PRAD	All	All	+0.729	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

DGKD–KIRC

Open the KIRC breakdown →