DGKD

Across TCGA patient cohorts, DGKD mutation is significantly associated with the RNA expression of many other genes, with 5,000 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGKD-associated genes across cancer lineages are DLGAP5, RFWD3, and EXO1. Each is linked with DGKD in more than 3 cancer types. Because this analysis shows association rather than direction, both DGKD-to-partner and partner-to-DGKD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DLGAP5 grouped by DGKD-low versus DGKD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKD→partner) and Y-score (partner→DGKD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DLGAP5 →	+0.493	+1.483	.007	.007	3	4
UCEC	RFWD3 →	+0.519	+2.078	<.001	<.001	3	3
COAD	EXO1 →	+0.850	+3.820	<.001	<.001	2	4
SKCM	RNA5SP477 →	+0.521	+2.488	.001	.003	3	3
UCEC	MIEF1 →	+0.360	+1.852	<.001	<.001	3	3
SKCM	POLE2 →	+0.622	+2.353	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,000 associations by consensus.

DLGAP5 by DGKD expression — UCEC

Explore this box plot interactively →