DGKD

Across TCGA patient cohorts, DGKD mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGKD-associated genes across cancer lineages are INPP4B, Caspase-7-cleavedD198, and ATM. Each is linked with DGKD in more than 2 cancer types. Because this analysis shows association rather than direction, both DGKD-to-partner and partner-to-DGKD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by DGKD-low versus DGKD-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKD→partner) and Y-score (partner→DGKD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	INPP4B →	-0.622	-3.169	<.001	.017	3	3
COAD	Caspase-7-cleavedD198 →	+1.095	+3.338	<.001	.004	3	3
UCEC	ATM →	-0.427	-1.584	.001	.002	3	3
BRCA	Chk1_pS345 →	+0.195	+2.820	.030	.036	3	2
COAD	EGFR_pY1068 →	-0.382	-3.169	.005	.017	3	2
COAD	eIF4E →	+0.206	+2.182	.005	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

INPP4B by DGKD expression — COAD

Explore this box plot interactively →