DGKD

Across TCGA cell cohorts, DGKD mutation is significantly associated with the RNA expression of many other genes, with 164 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DGKD-associated genes across cancer lineages are RNF227, OTC, and TBL1Y. Each is linked with DGKD in more than 1 cancer types. Because this analysis shows association rather than direction, both DGKD-to-partner and partner-to-DGKD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNF227 grouped by DGKD-low versus DGKD-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKD→partner) and Y-score (partner→DGKD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RNF227 →	+0.600	+3.301	.004	.003	3	2
PANCREAS	OTC →	+1.078	+3.491	.001	.008	3	1
PANCREAS	TBL1Y →	+0.004	+4.029	<.001	.007	3	1
BLOOD_Lymphoma	DMRTB1 →	+0.025	+3.714	<.001	.006	3	1
BLOOD_Lymphoma	SHCBP1L →	+0.036	+3.843	<.001	.007	3	1
BLOOD_Lymphoma	S100G →	+0.056	+4.452	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 164 associations by consensus.

RNF227 by DGKD expression — LARGE_INTESTINE

Explore this box plot interactively →