DGKB

Across TCGA patient cohorts, DGKB mutation is significantly associated with the RNA expression of many other genes, with 6,764 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGKB-associated genes across cancer lineages are CDCA2, FUT11, and SDHD. Each is linked with DGKB in more than 3 cancer types. Because this analysis shows association rather than direction, both DGKB-to-partner and partner-to-DGKB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDCA2 grouped by DGKB-low versus DGKB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKB→partner) and Y-score (partner→DGKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CDCA2 →	+0.685	+1.584	<.001	<.001	3	4
UCEC	FUT11 →	+0.286	+2.523	.006	<.001	3	4
UCEC	SDHD →	+0.407	+2.284	.003	<.001	3	4
UCEC	PAICS →	+0.551	+2.389	<.001	<.001	3	4
UCEC	OTUD3 →	+0.386	+1.290	<.001	.002	3	4
UCEC	ESCO2 →	+0.520	+1.955	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,764 associations by consensus.

CDCA2 by DGKB expression — UCEC

Explore this box plot interactively →