DGKB

Across TCGA pan-cancer cohorts, DGKB RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of DGKB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where DGKB RNA is repressed in tumor relative to normal tissue. In most cancer types DGKB is over-expressed in tumor, although a few such as KIRP and BLCA show the opposite, repressed pattern.

KIRP, BLCA, and KICH are the cancer types where DGKB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DGKB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	−0.700	<.001	11	view →
BLCA	All	III,IV	−1.153	.002	8	view →
KICH	All	All	−0.440	<.001	7	view →
UCEC	All	All	−1.580	<.001	6	view →
BRCA	All	All	−0.082	<.001	6	view →
STAD	All	All	−0.702	.005	5	view →
COAD	All	II,III,IV	−0.308	<.001	5	view →
LUSC	Male	All	+0.201	<.001	4	view →
KIRC	Male	All	−0.244	<.001	3	view →
READ	All	III,IV	−0.565	.007	2	view →
HNSC	Male	III,IV	+0.221	.017	2	view →
THCA	All	II,III,IV	−0.063	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

DGKB–KIRP

Open the KIRP breakdown →