DGKB

Across TCGA patient cohorts, DGKB mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGKB-associated genes across cancer lineages are Cyclin-B1, TFRC, and Caspase-7-cleavedD198. Each is linked with DGKB in more than 3 cancer types. Because this analysis shows association rather than direction, both DGKB-to-partner and partner-to-DGKB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by DGKB-low versus DGKB-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKB→partner) and Y-score (partner→DGKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-B1 →	+0.618	+3.016	.011	.018	3	4
UCEC	TFRC →	+0.373	+1.106	.012	.020	3	3
UCEC	Caspase-7-cleavedD198 →	+0.445	+1.604	.007	.005	3	3
LUSC	eIF4E →	+0.178	+3.009	.024	.019	2	3
LUAD	Rab11 →	-0.161	-2.321	.003	.006	3	2
UCEC	A-Raf_pS299 →	-0.080	-1.152	.017	.048	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Cyclin-B1 by DGKB expression — COAD

Explore this box plot interactively →