DGKB

Across TCGA cell cohorts, DGKB mutation is significantly associated with the RNA expression of many other genes, with 327 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DGKB-associated genes across cancer lineages are KRTAP13-2, ARGFX, and ANKRD20A4P. Each is linked with DGKB in more than 1 cancer types. Because this analysis shows association rather than direction, both DGKB-to-partner and partner-to-DGKB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP13-2 grouped by DGKB-low versus DGKB-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKB→partner) and Y-score (partner→DGKB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	KRTAP13-2 →	+0.229	+4.643	<.001	.008	3	2
UPPER_AERODIGESTIVE_TRACT	ARGFX →	+0.062	+4.357	<.001	.006	3	2
LARGE_INTESTINE	ANKRD20A4P →	+0.436	+3.169	<.001	.009	3	2
LUNG_NSCLC_LUAD	CSMD1 →	+1.089	+2.785	.001	.004	3	2
LUNG_NSCLC_LUSC	ARMH2 →	+0.020	+4.643	<.001	.008	3	1
UPPER_AERODIGESTIVE_TRACT	TAAR2 →	+0.067	+4.357	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 327 associations by consensus.

KRTAP13-2 by DGKB expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →