DGKA

Across TCGA pan-cancer cohorts, DGKA Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DGKA data layer compared with 23 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher DGKA Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated DGKA expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

SCLC, UCEC, and LUSC are the cancer types where DGKA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	II,III,IV	0.137	0.562	.013	9	view →
UCEC	DFS	Median	All	0.957	0.827	.020	8	view →
LUSC	DFS	Median	All	0.064	0.791	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DGKA–SCLC (DFS)

Open the SCLC breakdown →