DGKA

Across TCGA pan-cancer cohorts, DGKA RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of DGKA’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where DGKA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DGKA is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

KIRC, COAD, and LUAD are the cancer types where DGKA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DGKA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.785	<.001	9	view →
COAD	Female	All	−0.974	<.001	8	view →
LUAD	All	II,III,IV	+0.926	<.001	8	view →
LUSC	Male	All	+1.645	<.001	7	view →
KICH	Female	All	−1.098	<.001	6	view →
KIRP	All	All	+0.869	<.001	6	view →
HNSC	All	All	+0.624	<.001	6	view →
LIHC	Female	III,IV	+0.626	.003	5	view →
CHOL	Female	All	+2.166	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

DGKA–KIRC

Open the KIRC breakdown →