DGKA

Across TCGA patient cohorts, DGKA mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGKA-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and FASN. Each is linked with DGKA in more than 2 cancer types. Because this analysis shows association rather than direction, both DGKA-to-partner and partner-to-DGKA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by DGKA-low versus DGKA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKA→partner) and Y-score (partner→DGKA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.493	+2.502	<.001	.001	3	3
COAD	Caspase-7-cleavedD198 →	+1.034	+2.178	.005	.035	3	2
UCEC	FASN →	+0.295	+1.700	.023	.042	3	2
UCEC	PKC-b-II_pS660 →	-0.216	-1.392	.017	.019	3	2
UCEC	Cyclin-E2 →	+0.115	+1.331	.039	.043	3	2
COAD	GAPDH →	+0.619	+2.820	.009	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ASNS by DGKA expression — UCEC

Explore this box plot interactively →