DGKA

Across TCGA cell cohorts, DGKA RNA expression is significantly associated with the go_rna of many other GO terms, with 5,435 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible DGKA-associated GO terms across cancer lineages are Positive regulation of protein localization to plasma membrane, Cell-substrate junction assembly, and Negative regulation of actin filament depolymerization. Each is linked with DGKA in more than 12 cancer types. Because this analysis shows association rather than direction, both DGKA-to-partner and partner-to-DGKA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein localization to plasma membrane grouped by DGKA-low versus DGKA-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKA→partner) and Y-score (partner→DGKA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Positive regulation of protein localization to plasma membrane →	+0.110	+2.121	.003	.007	3	13
LUNG_NSCLC_LUAD	Cell-substrate junction assembly →	+0.198	+1.810	<.001	<.001	3	13
BONE	Negative regulation of actin filament depolymerization →	+0.177	+1.296	.002	<.001	3	13
BREAST	Cell-substrate junction organization →	+0.143	+1.813	.002	.003	3	12
BONE	Cell-substrate adhesion →	+0.168	+1.559	<.001	<.001	3	12
URINARY_TRACT	Small GTPase-mediated signal transduction →	+0.061	+1.847	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,435 associations by consensus.

Positive regulation of protein localization to plasma membrane by DGKA expression — KIDNEY

Explore this box plot interactively →