DGKA

Across TCGA cell cohorts, DGKA mutation is significantly associated with the RNA expression of many other genes, with 363 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DGKA-associated genes across cancer lineages are DPPA5, KRT25, and CBY1. Each is linked with DGKA in more than 1 cancer types. Because this analysis shows association rather than direction, both DGKA-to-partner and partner-to-DGKA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DPPA5 grouped by DGKA-low versus DGKA-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKA→partner) and Y-score (partner→DGKA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	DPPA5 →	+1.746	+5.285	<.001	.003	3	1
STOMACH	KRT25 →	+0.006	+5.285	<.001	.003	3	1
LARGE_INTESTINE	CBY1 →	+0.729	+3.160	<.001	.006	3	1
LARGE_INTESTINE	SGSM3 →	+0.825	+3.212	<.001	.006	3	1
LARGE_INTESTINE	DDX25 →	+0.100	+3.447	<.001	.002	3	1
LARGE_INTESTINE	HIPK3 →	+0.690	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 363 associations by consensus.

DPPA5 by DGKA expression — STOMACH

Explore this box plot interactively →