DGCR8

Across TCGA patient cohorts, DGCR8 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,255 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DGCR8-associated proteins across cancer lineages are NONO, RANBP1, and NXF1. Each is linked with DGCR8 in more than 4 cancer types. Because this analysis shows association rather than direction, both DGCR8-to-partner and partner-to-DGCR8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DGCR8 versus NONO in GBM, with a Pearson correlation of 0.64.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DGCR8→partner) and Y-score (partner→DGCR8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	NONO →	+0.206	+0.371	<.001	<.001	3	5
LSCC	RANBP1 →	+0.484	+0.548	<.001	<.001	3	5
LSCC	NXF1 →	+0.337	+0.729	<.001	<.001	3	5
GBM	WIZ →	+0.439	+0.503	<.001	<.001	3	5
LSCC	SUPT16H →	+0.430	+0.566	<.001	<.001	3	5
COAD	ATAD2 →	+0.464	+0.590	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,255 associations by consensus.

DGCR8 vs NONO — GBM

Explore this scatter interactively →