DFFB

Across TCGA cell cohorts, DFFB mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DFFB-associated genes across cancer lineages are RGR, CLRN1, and C6orf118. Each is linked with DFFB in more than 1 cancer types. Because this analysis shows association rather than direction, both DFFB-to-partner and partner-to-DFFB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RGR grouped by DFFB-low versus DFFB-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DFFB→partner) and Y-score (partner→DFFB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RGR →	+0.006	+5.087	<.001	.004	3	1
URINARY_TRACT	CLRN1 →	+0.033	+5.087	<.001	.004	3	1
LARGE_INTESTINE	C6orf118 →	+0.121	+3.793	.001	.007	3	1
LARGE_INTESTINE	CHIA →	+0.050	+3.930	<.001	.003	3	1
LARGE_INTESTINE	CSN2 →	+0.022	+3.684	.001	.006	3	1
LARGE_INTESTINE	SSMEM1 →	+0.030	+3.707	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

RGR by DFFB expression — URINARY_TRACT

Explore this box plot interactively →