DFFA

Across TCGA pan-cancer cohorts, DFFA mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DFFA data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DFFA mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DFFA expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

LUAD, HNSC, and GBM are the cancer types where DFFA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	All	0.864	0.400	.002	23	view →
HNSC	DFS	Quartile	All	0.914	1.000	.023	15	view →
GBM	OS	Median	All	0.685	0.401	<.001	13	view →
PDAC	DFS	Quartile	III,IV	0.880	0.292	.006	9	view →
CCRCC	DFS	Tertile	III,IV	0.904	0.125	.024	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DFFA–LUAD (DFS)

Open the LUAD breakdown →