DFFA

Across TCGA pan-cancer cohorts, DFFA RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of DFFA’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where DFFA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DFFA is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, LIHC, and BLCA are the cancer types where DFFA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DFFA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+0.919	<.001	10	view →
LIHC	Female	II,III,IV	+0.931	<.001	8	view →
BLCA	All	All	+0.589	.001	8	view →
HNSC	All	III,IV	+0.511	<.001	8	view →
THCA	Male	All	−0.358	<.001	8	view →
LUAD	All	All	+0.288	<.001	7	view →
STAD	Male	II,III,IV	+0.895	<.001	6	view →
KICH	Female	II,III,IV	−0.952	<.001	5	view →
LUSC	Male	II,III,IV	+0.641	<.001	5	view →
KIRC	Male	All	−0.259	.003	4	view →
BRCA	Female	All	−0.212	.002	4	view →
CHOL	Male	All	+1.288	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

DFFA–COAD

Open the COAD breakdown →